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Ferrostatin-1 |
347174-05-4 |
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Cat.No.: |
IC-0121491 |
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Product Information |
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Biological Activity |
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Ferrostatin-1, a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity[1][2][3].IC50 & Target:EC50: 60 nM (Ferroptosis)[1]Ferrostatin-1 (Fer-1) prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices[1]. |
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Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines) |
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Species |
Mouse |
Rat |
Rabbit |
Guinea pig |
Hamster |
Dog |
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Weight (kg) |
0.02 |
0.15 |
1.8 |
0.4 |
0.08 |
10 |
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Body Surface Area (m2) |
0.007 |
0.025 |
0.15 |
0.05 |
0.02 |
0.5 |
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Km factor |
3 |
6 |
12 |
8 |
5 |
20 |
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Animal A (mg/kg) = Animal B (mg/kg) multiplied by (Animal B Km / Animal A Km) |
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Order Information |
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Quantity |
Price($) |
Price($) |
Availability |
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5mg |
$95.00 |
€104.50 |
In stock |
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25mg |
$170.00 |
€187.00 |
In stock |
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500mg |
$980.00 |
€1,078.00 |
In stock |
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Free Delivery on orders over $350.00. |
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Chemical Information |
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Molecular Weight |
262.35 |
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Formula |
C15H22N2O2 |
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CAS Number |
347174-05-4 |
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Purity |
>98% |
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Solubility |
DMSO : 125 mg/mL (476.46 mM; Need ultrasonic) |
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Storage |
4¡ãC, protect from light*In solvent : -80¡ãC, 6 months; -20¡ãC, 1 month (protect from light) |
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Reference |
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[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072. |
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We Devoted Ourselves To The Development Of Biomedical Research Reagent. |
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