Product Information

Biological Activity

Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 ¦ÌM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-¦ÊB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells[1][2].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

50mg

$250.00

€275.00

In stock

200mg

$850.00

€935.00

In stock

500mg

$2,200.00

€2,420.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

234.3

Formula

C₁₅H₂₂O₂

CAS Number

19431-84-6

Purity

>99.00%

Solubility

DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 0.3 mg/ml

Storage

 at -20¡ãC

Reference

[1]. Sun DX, et al. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24(8):1213-6.
[2]. Lo JY, et al. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-¦ÊB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6(11):3550-9.

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