MOTS-c(Polypeptide)

Cat.No.:

IC-0918666

Product Information

Biological Activity

MOTS-c is a mitochondrial-derived peptide. MOTS-c induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c induces glucose uptake and improves insulin sensitivity. MOTS-c has implications in the regulation of obesity, diabetes, exercise, and longevity[1].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Quantity

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

10mg

€ 160.00

£¤192.00

£¤1,600.00

$31,840.00

50mg

€ 475.00

£¤570.00

£¤4,750.00

$94,525.00

100mg

€ 675.00

£¤810.00

£¤6,750.00

$134,325.00

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

2234.64

Formula

C₁₀₃H₁₅₆N₂₈O₂₄S₂

CAS Number

N/A

Purity

>98.50%

Solubility

DMSO : 4 mg/mL (1.79 mM; Need ultrasonic)

Storage

 at -20¡ãC

Reference

[1]. Changhan Lee, et al. MOTS-c: A Novel Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism. Free Radic Biol Med. 2016 Nov;100:182-187.

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