Cat.No.:

IC-0221553

Product Information

Biological Activity

Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-¦ÊB signaling pathway[1].
Curculigoside (1-64 ¦Ìg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 ¦Ìg/ml in MH7A cells[1].Curculigoside (4-16 ¦Ìg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-¦Á group[1].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

10mg

$160.00

€176.00

In stock

20mg

$260.00

€286.00

In stock

50mg

$420.00

€462.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

466.44

Formula

C₂₂H₂₆O₁₁

CAS Number

85643-19-2

Purity

 >99.50%

Solubility

¡Ý 23.3mg/mL in EtOH with ultrasonic

Storage

4¡ãC, protect from light

Reference

[1]. Tan S, et al. Curculigoside exerts significant anti arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF ¦ÊB signaling pathway. Mol Med Rep. 2019 Mar;19(3):2057-2064.

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