Cat.No.:

IC-0235804

Product Information

Biological Activity

Folic acid  is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

500mg

$200.00

€240.00

In stock

1g

$380.00

€456.00

In stock

5g

$1,200.00

€1,440.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

441.4

Formula

C19H19N7O6

CAS Number

59-30-3

Purity

99.56%

Solubility

1M NaOH : 100 mg/mL (226.55 mM; Need ultrasonic) DMSO : 33.33 mg/mL (75.51 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

Storage

2-8¡ãC, protect from light

Reference

[1].Hathairat Sawaengsri, et al. J Nutr Biochem. High Folic Acid Intake Reduces Natural Killer Cell Cytotoxicity in Aged Mice

[2].Patanwala I, et al. Am J Clin Nutr. Folic acid handling by the human gut: implications for food fortification and supplementation.

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