Product Information

Biological Activity

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. Dexamethasone also inhibits induction of nitric oxide synthase with IC50 of 5 nM. Dexamethasone reduces levels of activated NF-¦ÊB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Dexamethasone induces differentiation of human mesenchymal stem cells (MSCs). Dexamethasone also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

500mg

$150.00

€180.00

In stock

1g

$230.00

€276.00

In stock

5g

$850.00

€1,020.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

392.47

Formula

C22H29FO5

CAS Number

50-02-2

Purity

¡Ý98.00%

Solubility

DMSO¡Ü 50 mg/mL

Storage

4¡ãC, protect from light, dry, sealed

Reference

[1].Sittichokechaiwut A, et al. Eur Cell Mater. Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

[2].Laane E, et al. Cell Death Differ. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy.

We Devoted Ourselves To The Development Of Biomedical Research Reagent.