Product Information

Biological Activity

¦Â-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. ¦Â-Glycerophosphate disodium salt hydrate is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

500mg

$60.00

€72.00

In stock

1g

$95.00

€114.00

In stock

5g

$480.00

€576.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

306.11

Formula

C3H7Na2O6P¡¤5H2O

CAS Number

13408-09-8

Purity

¡Ý98% (NT)

Solubility

200mg/ml in water

Storage

2-8¡ãC, protect from light, dry, sealed

Reference

[1].Chung CH, et al. Calcif Tissue Int. Mechanism of action of beta-glycerophosphate on bone cell mineralization.

[2].Shioi A, et al. Arterioscler Thromb Vasc Biol. Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells.

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