Product Information

Biological Activity

Indocyanine green (Cardiogreen) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow,and for ophthalmic angiography. It has a peak spectral absorption at about 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than Fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice.    

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

10mg

$90.00

€108.00

In stock

100mg

$650.00

€780.00

In stock

500mg

$1,600.00

€1,920.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

774.96

Formula

C43H47N2NaO6S2

CAS Number

3599-32-4

Purity

>98.00%

Solubility

DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.5 mg/ml

Storage

Store at -20¡ãC ,protect from light

Reference

[1].Claire Egloff-Juras, et al. NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green.

[2].Michaela B Reinhart, et al. Indocyanine Green: Historical Context, Current Applications, and Future Considerations.

We Devoted Ourselves To The Development Of Biomedical Research Reagent.