Product Information

Biological Activity

N-hydroxysuccinimide can be synthesized by dehydration reaction in carboxylic acid in the presence of dicyclohexyl carbon diimide.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

1g

$75.00

€90.00

In stock

5g

$260.00

€312.00

In stock

25g

$750.00

€900.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

115.09

Formula

C4H5NO3

CAS Number

6066-82-6

Purity

>99.00%

Solubility

¡Ý 11.5mg/mL in DMSO, ¡Ý 28.95 mg/mL in EtOH with ultrasonic, ¡Ý 119 mg/mL in Water

Storage

Store at RT

Reference

[1].Chang Wang, et al. Anal Chim Acta. Fmoc N-hydroxysuccinimide ester: A facile and multifunctional role in N-glycan analysis

[2].Eric A Berg, et al. Cold Spring Harb Protoc. Labeling Antibodies with N-Hydroxysuccinimide-Long Chain (NHS-LC)-Biotin

[3].Marc-Andr Kasper, et al. Chembiochem. N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

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