Product Information

Biological Activity

Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

5g

$230.00

€276.00

In stock

25g

$950.00

€1,140.00

In stock

50g

$1,585.00

€1,902.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

374.47

Formula

C22H30O5

CAS Number

83-43-2

Purity

¡Ý98%

Solubility

DMSO£º£¼125 mg/mL

Storage

2~8¡ãC

Reference

[1].Ali Tabatabai, et al. Methylprednisolone may be associated with improved lung compliance in acute respiratory distress syndrome patients on veno-venous extracorporeal membrane oxygenation

[2].Antonio Torrelo. Methylprednisolone aceponate for atopic dermatitis

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