Urolithin A ,1143-70-0

Cat.No.:

IC-0100734

Product Information

Biological Activity

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

5mg

$100.00

€120.00

In stock

25mg

€350.00

€420.00

In stock

100mg

$840.00

€1,008.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

228.2

Formula

C13H8O4

CAS Number

1143-70-0

Purity

¡Ý99.0%

Solubility

DMSO:30mg/mL(131.46mM; Need ultrasonic)

Storage

at-20¡æ

Reference

[1].Gong Z, et al. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice.

[2].Wang Y, et al. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29(5):1107-15.

We Devoted Ourselves To The Development Of Biomedical Research Reagent.