Resveratrol,501-36-0

Cat.No.:IC-0111016

Product Information

Biological Activity

Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin. Resveratrol is a potent reducing agent, and can prevent carcinogenesis due to its anti-oxidant abilities [1]. Resveratrol has a broad range of targets, including cyclooxygenase (e.g., COX, IC50=1.1 ¦ÌM), lipoxygenase (LOC, IC50=2.7 ¦ÌM), STAT3 (IC50=20 ¦ÌM), and other proteins [2,3].
Resveratrol treatment is found to exert its effect on renal cell carcinoma (RCC) proliferation, migration and invasion in a concentration dependent manner through inactivation of the Akt and ERK1/2 signaling pathways [4]. In CaCo-2 cells, treatment with 25 ¦ÌM Resveratrol has shown 70% growth inhibition due to S/G2 phase arrest [5]. Resveratrol treatment lead to inhibited invasion and metastasis of colorectal cancer-derived cell lines LoVo and HCT116 by suppressing the Wnt/¦Â-catenin signaling mediated target genes of c-Myc, MMP-7, and MALT-1[6].
Resveratrol is shown to be effective against breast cancer metastasis to lungs in mice by its inhibitory effect on Stat3 mediated signaling [7]. Resveratrol treatment reduced size and number of tumor spheres in renal carcinoma stem cells xenograft mice model [8]. Resveratrol treatment reduced Epithelial to mesenchymal transition (EMT) of glioblastoma U87 xenografted mice models [9].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price(€)

Price(£¤/CNY)

1g

$60.00

€72.00

£¤600.00

10g

$162.5.00

€195.00

£¤1,625.00

25g

$1050.40

€1260.50

£¤10,504.00

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

228.24

Formula

C14H12O3

CAS Number

501-36-0

Purity

>99.50%

Solubility

9.65 mg/mL in DMSO, 48.2 mg/mL in EtOH with ultrasonic.

Storage

 -20¡æ

Reference

[1]. Bhaskara V K, Mittal B, Mysorekar V V, et al. Resveratrol, cancer and cancer stem cells: A review on past to future[J]. Current Research in Food Science, 2020, 3: 284-295.

[2]. Calamini B, Ratia K, Malkowski M G, et al. Pleiotropic mechanisms facilitated by resveratrol and its metabolites[J]. Biochemical Journal, 2010, 429(2): 273-282.

[3]. Pirola L, Fr?jd? S. Resveratrol: one molecule, many targets[J]. IUBMB life, 2008, 60(5): 323-332.

[4]. Zhao Y, Tang H, Zeng X, et al. Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells[J]. Biomedicine & Pharmacotherapy, 2018, 98: 36-44.

[5]. Schneider Y, Vincent F, Duranton B, et al. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells[J]. Cancer letters, 2000, 158(1): 85-91.

[6]. Ji Q, Liu X, Fu X, et al. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/¦Â-catenin signal pathway[J]. PloS one, 2013, 8(11): e78700.

[7]. Lee-Chang C, Bodogai M, Martin-Montalvo A, et al. Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells[J]. The Journal of Immunology, 2013, 191(8): 4141-4151.

[8]. Ji Q, Liu X, Fu X, et al. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/¦Â-catenin signal pathway[J]. PloS one, 2013, 8(11): e78700.

[9]. Song Y, Chen Y, Li Y, et al. Resveratrol suppresses epithelial-mesenchymal transition in GBM by regulating Smad-dependent signaling[J]. BioMed Research International, 2019, 2019.

We Devoted Ourselves To The Development Of Biomedical Research Reagent.