MPP+ iodide,36913-39-0

Cat.No.:IC-0211401

Product Information

Biological Activity

MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson''''s disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price(€)

Price(£¤/CNY)

25mg

$80.00

€96.00

£¤800.00

100mg

$210.00

€252.00

£¤2,100.00

500mg

$980.00

€1,176.00

£¤9,800.00

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

297.14

Formula

C12H12IN

CAS Number

36913-39-0

Purity

>99.00%

Solubility

DMSO£º100 mg/ml,Water£º100 mg/ml.

Storage

4¡ãC, sealed storage, away from moisture and light

Reference

[1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.

[2]. Mart¨ª Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45.  

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