Reagent
Antibody
Primary Antibody
Anti SDF1/CXCL12 antibody£¬2048061
Click£º2650 Release date£º2019-5-6 Author£ºAdministrator Source£ºOriginal
|
Anti SDF1/CXCL12 antibody
|
|
Cata.No.
|
2048061
|
|
|
|
Host
|
Rabbit
|
|
|
Isotype
|
IgG
|
|
|
Conjugation
|
Unconjugated
|
|
|
Reactivity
|
Human, Mouse, Rat
|
|
Applacition
|
WB
|
1:500-1:2000
|
|
|
|
IHC
|
1:50-1:200
|
|
|
|
IF/ICC
|
1:50-1:200
|
|
|
|
IP
|
N/A
|
|
|
|
CHIP
|
N/A
|
|
|
|
ELISA
|
1:4000-1:6000
|
|
|
|
|
|
|
|
Uniprot
|
P48061
|
|
|
Gene ID
|
CXCL12(6387)
|
|
Western Blot; Sample: Recombinant SDF1, Mouse.1/800
|
|
Mass (Da)
|
11KD
|
|
|
Localization
|
Secreted.
|
|
Storage
|
-20¡æ
|
|
|
|
|
Immunogen
|
Recombinant Mouse SDF1 Lys22~Lys89 with N-terminal His Tag in E.coli.
|
|
|
|
|
|
|
|
Alternative Names
|
|
|
|
12-O-tetradecanoylphorbol 13-acetate repressed protein 1;AI174028;C-X-C motif chemokine 12;Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1);Chemokine (C-X-C motif) ligand 12;Chemokine CXC motif ligand 12;cxcl12;hIRH;hSDF-1;Intercrine reduced in hepatomas;IRH;OTTHUMP00000019491;PBSF;Pre-B cell growth-stimulating factor;SCYB12;SDF 1;SDF-1;SDF-1-alpha(3-67);SDF-1a;SDF-1b;SDF1_HUMAN;SDF1A;SDF1B;Stromal cell-derived factor 1;Stromal cell-derived factor 1 delta;Stromal cell-derived factor 1 gamma;Stromal cell-derived factor 1a;Stromal cell-derived factor-1 alpha;Thymic lymphoma cell-stimulating factor;Tlsf;TLSF-a;TLSF-b;Tlsfa;Tlsfb;TPAR1
|
|
|
|
|
|
|
|
BackGround
|
|
|
|
In adulthood, CXCL12 plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPCs) from the bone marrow through a CXCR4 dependent mechanism (PMID: 17878755). It is this function of CXCL12 that makes it a very important factor in carcinogenesis and the neovascularisation linked to tumour progression (PMID: 16943240). CXCL12 also has a role in tumor metastasis where cancer cells that express the receptor CXCR4 are attracted to metastasis target tissues that release the ligand, CXCL12 (PMID: 11242036 ). In breast cancer, however, increased expression of CXCL12 determines a reduced risk of distant metastasis (PMID: 19646861; 17724466 ). This antibody can detect all the isoforms of CXCL12/SDF1.
|
|
|
|
|
|
|
|
Reference
|
|
|
|
1. Ota T, Suzuki Y, Nishikawa T,Sugano S. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5.
|
|
2. Yu L, Cecil J, Su EW, Wang J. Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene. 2006 Jun 7;374:174-9.
|
|
3. Shirozu M, Nakano T, Honjo T. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics. 1995 Aug 10;28(3):495-500.
|
|
Order Information
|
|
Cat./REF.
|
Size
|
Price($£©
|
Price(€)
|
Price(£¤/CNY£©
|
Price(£¤/JYP£©
|
|
2048061
|
25ul
|
$196.00
|
€ 235.20
|
£¤1,960.00
|
£¤39,004.00
|
|
2048061
|
50ul
|
$280.00
|
€ 336.00
|
£¤2,800.00
|
£¤55,720.00
|
|
2048061
|
100ul
|
$448.00
|
€ 537.60
|
£¤4,480.00
|
£¤89,152.00
|
|
Next article£ºNo article
