Reagent
Antibody
Primary Antibody
Anti SDF1/CXCL12 antibody£¬2048061
Click£º2862 Release date£º2019-5-6 Author£ºAdministrator Source£ºOriginal
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Anti SDF1/CXCL12 antibody
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Cata.No.
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2048061
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Host
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Rabbit
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Isotype
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IgG
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Conjugation
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Unconjugated
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Reactivity
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Human, Mouse, Rat
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Applacition
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WB
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1:500-1:2000
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IHC
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1:50-1:200
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IF/ICC
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1:50-1:200
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IP
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N/A
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CHIP
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N/A
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ELISA
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1:4000-1:6000
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Uniprot
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P48061
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Gene ID
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CXCL12(6387)
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Western Blot; Sample: Recombinant SDF1, Mouse.1/800
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Mass (Da)
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11KD
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Localization
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Secreted.
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Storage
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-20¡æ
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Immunogen
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Recombinant Mouse SDF1 Lys22~Lys89 with N-terminal His Tag in E.coli.
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Alternative Names
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12-O-tetradecanoylphorbol 13-acetate repressed protein 1;AI174028;C-X-C motif chemokine 12;Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1);Chemokine (C-X-C motif) ligand 12;Chemokine CXC motif ligand 12;cxcl12;hIRH;hSDF-1;Intercrine reduced in hepatomas;IRH;OTTHUMP00000019491;PBSF;Pre-B cell growth-stimulating factor;SCYB12;SDF 1;SDF-1;SDF-1-alpha(3-67);SDF-1a;SDF-1b;SDF1_HUMAN;SDF1A;SDF1B;Stromal cell-derived factor 1;Stromal cell-derived factor 1 delta;Stromal cell-derived factor 1 gamma;Stromal cell-derived factor 1a;Stromal cell-derived factor-1 alpha;Thymic lymphoma cell-stimulating factor;Tlsf;TLSF-a;TLSF-b;Tlsfa;Tlsfb;TPAR1
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BackGround
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In adulthood, CXCL12 plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPCs) from the bone marrow through a CXCR4 dependent mechanism (PMID: 17878755). It is this function of CXCL12 that makes it a very important factor in carcinogenesis and the neovascularisation linked to tumour progression (PMID: 16943240). CXCL12 also has a role in tumor metastasis where cancer cells that express the receptor CXCR4 are attracted to metastasis target tissues that release the ligand, CXCL12 (PMID: 11242036 ). In breast cancer, however, increased expression of CXCL12 determines a reduced risk of distant metastasis (PMID: 19646861; 17724466 ). This antibody can detect all the isoforms of CXCL12/SDF1.
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Reference
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1. Ota T, Suzuki Y, Nishikawa T,Sugano S. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5.
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2. Yu L, Cecil J, Su EW, Wang J. Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene. 2006 Jun 7;374:174-9.
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3. Shirozu M, Nakano T, Honjo T. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics. 1995 Aug 10;28(3):495-500.
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Order Information
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Cat./REF.
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Size
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Price($£©
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Price(€)
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Price(£¤/CNY£©
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Price(£¤/JYP£©
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2048061
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25ul
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$196.00
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€ 235.20
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£¤1,960.00
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£¤39,004.00
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2048061
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50ul
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$280.00
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€ 336.00
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£¤2,800.00
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£¤55,720.00
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2048061
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100ul
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$448.00
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€ 537.60
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£¤4,480.00
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£¤89,152.00
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