Bv421 Anti-Human CD16£¬F100160
Description
The CB16 monoclonal antibody recognizes CD16 (Fc gammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody- dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
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Product Information |
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Size |
25/100/200 Tests |
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Species Reactivity |
Human |
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Published Species |
Human |
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Host/Isotype |
Mouse / IgG1, kappa |
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Recommended Isotype Control |
Mouse IgG1 kappa Isotype Control Bv421 |
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Class |
Monoclonal |
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Type |
Antibody |
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Clone |
CB16 |
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Conjugate |
Bv421 |
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Excitation/Emission Max |
405/445 nm |
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Form |
Liquid |
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Concentration |
5 µL/Test |
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Purification |
Affinity chromatography |
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Storage buffer |
PBS, pH 7.2, with 0.2% BSA |
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Contains |
0.09% sodium azide |
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Storage conditions |
4¡ã C, store in dark, DO NOT FREEZE! |
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Applications |
Tested Dilution |
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Immunocytochemistry (ICC/IF) |
Based on experimental optimization |
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Flow Cytometry (Flow) |
5 µL (0.25 µg)/test |
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T-Cell Activation (TCA) |
Based on experimental optimization |
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Order Information |
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Cat./REF. |
Size |
Price($£© |
Price(€) |
Price(£¤/CNY£© |
Price(£¤/JYP£© |
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F100160 |
25Tests |
$260.00 |
€ 312.00 |
£¤2,600.00 |
£¤51,740.00 |
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F100160 |
100Tests |
$485.00 |
€ 582.00 |
£¤4,850.00 |
£¤96,515.00 |
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F100160 |
200Tests |
$760.00 |
€ 912.00 |
£¤7,600.00 |
£¤151,240.00 |
