HC-030031,IC-0206793
HC-030031 is a potent and selective TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2¡À0.2 and 5.3¡À0.2 ¦ÌM, respectively.
[1]. McNamara CR, et al. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30.
[2]. Eid SR, et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 2008 Oct 27;4:48.
[3]. Lennertz RC, et al. TRPA1 mediates mechanical sensitization in nociceptors during inflammation. PLoS One. 2012;7(8):e43597.
[4]. Miyake T, et al. Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun. 2016 Sep 15;7:12840.
[5]. So K, et al. Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice. Sci Rep. 2016 Mar 17;6:23261.
Order Information
Cat./REF.
Size
Price($£©
Price(€)
Price(£¤/CNY£©
Price(£¤/JYP£©
IC-0206793
1ml(10mM)
$46.50
€ 55.80
£¤465.00
£¤9,253.50
IC-0206793
5mg
$45.00
€ 54.00
£¤450.00
£¤8,955.00
IC-0206793
50mg
$122.00
€ 146.40
£¤1,220.00
£¤24,278.00
