Cetylpyridinium Chloride (CPC),123-03-5,IC-02149532

Cetylpyridinium Chloride (CPC), a broad-spectrum antimicrobial agent, has an extensive antimicrobial spectrum. The virucidal effect of CPC occurred within 10 minutes, with mean EC50 and EC2log ranging between 5 to 20 ¦Ìg/mL. The antimicrobial agent CPC possesses virucidal activity against susceptible and resistant strains of influenza virus by targeting and disrupting the viral envelope. Substantial virucidal activity is seen even at very low concentrations of CPC without development of resistance[3]. CPC inhibited both mitochondrial O2 consumption [half maximal inhibitory concentration IC50: 3.8 ¦ÌM] and ATP synthesis (IC50: 0.9 ¦ÌM). In addition, CPC showed concentration-dependent antiestrogenic activity with half maximal effective concentration EC50 of 4.5 ¦ÌM[4].
[1]Haps S, Slot DE, et al. The effect of cetylpyridinium chloride-containing mouth rinses as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review. Int J Dent Hyg. 2008 Nov;6(4):290-303.
[2]Pitten FA, Kramer A. Efficacy of cetylpyridinium chloride used as oropharyngeal antiseptic. Arzneimittelforschung. 2001;51(7):588-95.
[3]Popkin DL, Zilka S, Dimaano M, Fujioka H, Rackley C, Salata R, Griffith A, Mukherjee PK, Ghannoum MA, Esper F. Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo. Pathog Immun. 2017;2(2):252-269.
[4]Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G. In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride. Environ Health Perspect. 2017 Aug 22;125(8):087015.