Salvinorin B,  92545-30-7,IC-0386529

Product Introduction

Salvinorin B is a selective and brain-penetrant kappa opioid receptor (KOPr) agonist with an EC50 of 248 nM and a Ki of 2.95 µM. Salvinorin B activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response. Salvinorin B can be used for research in inflammation, immunology, and neurological diseases, such as neuropathic pain, multiple sclerosis, and anxiety.

Product Features

1. Selective KOPr Agonist: Activates kappa opioid receptor signaling with an EC50 of 248 nM.

2. Brain-Penetrant: Crosses the blood-brain barrier, enabling central nervous system research applications.

3. Anti-Inflammatory and Analgesic Activity: Inhibits pain transmission and reduces inflammatory responses.

4. Broad Research Utility: Suitable for studies of neuropathic pain, multiple sclerosis, anxiety, and immune regulation.

5. High Purity: Supplied at 99%+ purity for reproducible pharmacological studies.

Specifications

Size: 1 mg / 5 mg

CAS Number: 92545-30-7

Purity: 99%+

Molecular Weight: 432.46

Molecular Formula: C21H28O8

Solubility: DMSO: ¡Ý10 mg/mL; Ethanol: ¡Ý5 mg/mL; limited solubility in aqueous buffers

Storage and Stability

Storage Conditions: Store at -20¡ãC, sealed, away from moisture and light.

Shelf Life: The product is stable for 24 months from the date of manufacture when stored as directed. For reconstituted solutions, aliquot and store at -20¡ãC protected from light. Avoid repeated freeze-thaw cycles.

Protocol (For Reference Only)

Important: Protect from light and moisture during handling and storage. Prepare stock solutions in anhydrous DMSO.

1. Stock Solution Preparation: Dissolve Salvinorin B in anhydrous DMSO to prepare a concentrated stock solution (e.g., 10-50 mM). Aliquot into single-use vials and store at -20¡ãC protected from light.

2. In Vitro Working Solution Preparation: Dilute DMSO stock solution into culture medium or assay buffer to achieve working concentrations typically ranging from 0.1-10 µM. Limit final DMSO concentration to ¡Ü0.1%.

3. KOPr Activation Assay: Treat cells expressing KOPr with Salvinorin B at concentrations ranging from 0.1-10 µM. Assess receptor activation by measuring downstream signaling, such as G protein activation, ¦Â-arrestin recruitment, or inhibition of adenylyl cyclase activity.

4. Anti-Inflammatory and Analgesic Studies: Use Salvinorin B at appropriate concentrations in cell-based or animal models to evaluate effects on inflammatory cytokine production and pain transmission.

5. In Vivo Studies: Salvinorin B has been administered in rodent models; optimize dosing and route based on specific experimental requirements and published literature.

Precautions

1. Protect from light and moisture during handling and storage.

2. Use appropriate vehicle controls in all experiments; DMSO concentration in culture medium should not exceed 0.1%.

3. Salvinorin B is a potent psychoactive compound; handle with appropriate safety precautions.

4. For research use only. Not for use in diagnostic or therapeutic procedures.

FAQ (Simplified)

Q1: What is the mechanism of action of Salvinorin B?

A1: Salvinorin B is a selective kappa opioid receptor (KOPr) agonist that activates downstream signaling pathways by binding to KOPr, inhibiting pain transmission and reducing inflammatory responses.

Q2: What is the recommended concentration for in vitro studies?

A2: Typical in vitro working concentrations range from 0.1-10 µM. Optimize for each cell type and endpoint.

Q3: How should I store Salvinorin B?

A3: Store at -20¡ãC sealed, away from moisture and light. Reconstituted stock solutions should be aliquoted and stored at -20¡ãC protected from light.

Disclaimer

1. For Research Use Only. Not for use in diagnostic or therapeutic procedures.

2. Due to the variable nature of biological research, optimization of conditions is recommended for specific experimental systems.

3. This warranty is limited to the replacement of the product. The manufacturer assumes no liability for incidental or consequential damages.

4. Wear appropriate protective clothing and gloves when handling this product.

Ordering Information

Catalog Number: IC-0386529

Product Name: Salvinorin B

Size: 1 mg / 5 mg

Suggested Retail Price:

1 mg: CNY ¥1980.00 / USD $198.00 / EUR €237.60 / JPY ¥35640.00

5 mg: CNY ¥6500.00 / USD $650.00 / EUR €780.00 / JPY ¥117000.00

Note: The specific price is subject to the transaction price in the offline contract. This document is provided for technical reference only and does not constitute any form of sales advertisement or invitation to offer. For product details and purchase inquiries, please contact local sales representatives.