L-Leucyl-L-Leucine methyl ester,HCl(IC-016008)
Product Description
L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells.1,2 It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells.2 Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.2
Technical Information
Formal Name:L-leucyl-L-leucine, methyl ester, monohydrochloride
CAS Number:6491-83-4
Synonyms:LLME,LLOMe
Molecular Formula:C13H26N2O3 • HCl
Formula Weight:294.8
Purity:≥95%
Formulation:A crystalline solid
SMILES:COC([C@@H](NC([C@@H](N)CC(C)C)=O)CC(C)C)=O.Cl
InChi Code:InChI=1S/C13H26N2O3.ClH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5;/h8-11H,6-7,14H2,1-5H3,(H,15,16);1H/t10-,11-;/m0./s1
InChi Key:RVXQFTNCULOWRV-ACMTZBLWSA-N
Shipping & Storage Information
Storage:-20°C
Shipping:Room Temperature in continental US; may vary elsewhere
Stability:≥ 2 years
Order Information
Product Name
Cat.No.
Quantity
Price($)
Price($)
Availability
L-Leucyl-L-Leucine methyl ester,HCl
IC-016008
100mg
$112.00
�93.33
In stock
L-Leucyl-L-Leucine methyl ester,HCl
IC-016008
250mg
$162.00
�135.00
In stock
L-Leucyl-L-Leucine methyl ester,HCl
IC-016008
1g
$420.00
�350.00
In stock
WARNING This product is not for human or veterinary use.
