Cat.No.:IC-0151777
Product Information
Biological Activity
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species
Mouse
Rat
Rabbit
Guinea pig
Hamster
Dog
Weight (kg)
0.02
0.15
1.8
0.4
0.08
10
Body Surface Area (m2)
0.007
0.025
0.15
0.05
0.02
0.5
Km factor
3
6
12
8
5
20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by (Animal B Km / Animal A Km)
Order Information
Quantity
Price($)
Price($)
Availability
5g
$80.00
€88.00
In stock
25g
$120.00
€132.00
In stock
100g
$350.00
€385.00
In stock
Free Delivery on orders over $350.00.
Chemical Information
Molecular Weight
267.3
Formula
C14H21NO4
CAS Number
632-93-9
Purity
>98%
Solubility
DMF: 30 mg/ml,DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
Storage
at -20¡ãC
We Devoted Ourselves To The Development Of Biomedical Research Reagent.
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
