Cat.No.:IC-01281391

Product Information

Biological Activity

Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells[1][2][3].
In Vitro£ºNotoginsenoside R1 (2.5¨C80 ¦ÌM; 24 h) inhibits hypoxia/reoxygenation-induced cell death, intracellular ROS accumulation, and mitochondrial membrane depolarization in H9c2 cardiomyocytes[1].
Notoginsenoside R1 (5¨C20 ¦ÌM; 24 h) inhibits hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes in a concentration-dependent manner[1].
Notoginsenoside R1 (1¨C100 ¦ÌM; 24 h) dose-dependently protects PC12 cells and primary neurons against A¦Â-induced cell death and apoptosis[2].
Notoginsenoside R1 (10 ¦ÌM; 24 h) inhibits A¦Â25¨C35-induced ROS production, mitochondrial damage, and MAPK activation in PC12 cells[2].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

M.Weight

933.13

Formula

C47H80O18

CAS No.

80418-24-2

Purity

¡Ý98%

Solubility

DMSO: 100 mg/mL (107.17 mM£©

Storage

2-8¡æ, protect from light

Reference

[1]. Yu Y, et, al. Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways. Sci Rep. 2016 Feb 18;6:21730.
[2]. Ma B, et, al. Notoginsenoside R1 attenuates amyloid-¦Â-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. Int Immunopharmacol. 2014 Sep;22(1):151-9.
[3]. Sun K, et, al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Life Sci. 2007 Jul 19;81(6):509-18.

Order Information

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

5mg

$80.00

€ 96.00

£¤800.00

£¤15,920.00

50mg

$220.00

€ 264.00

£¤2,200.00

£¤43,780.00

100mg

$320.00

€ 384.00

£¤3,200.00

£¤63,680.00

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