Indocyanine Green

Cat.No.£ºIC-013577

Product Information

Biological Activity

  Indocyanine green (Cardiogreen) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow,and for ophthalmic angiography. It has a peak spectral absorption at about 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than Fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice.                                                 

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information

Molecular Weight

774.96

Formula

C43H47N2NaO6S2

CAS Number

3599-32-4

Purity

>94%

Solubility

25¡ãC water 1mg/mL

Storage

4¡ãC

Order Information

Product Name

Cat.No.

Quantity

Price($)

Price(€)

Availability

Indocyanine Green

IC-013577

50mg

$65.00

€54.17

In stock

Indocyanine Green

IC-013577

200mg

$230.00

€191.67

In stock

Indocyanine Green

IC-013577

1g

$570.00

€475.00

In stock

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