Carprofen

 Cat.No.£ºIC-012495

Product Information

Biological Activity

Carprofen inhibits canine COX2 with IC50 of 0.03 mM.

Cell experiment [1]:

Cell lines£º

gastric mucosa

Preparation method£º

The solubility of this compound in DMSO is >11.1mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37¡æ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20¡æ for several months.

Reacting condition£º

40 or 400 ¦Ìg/mL

Applications£º

In the gastric mucosa of dogs, carprofen increased in vitro conductance and permeability to mannitol. Carprofen (400 ¦Ìg/mL) caused sloughing of epithelial cells. Carprofen appeared to compromise gastric mucosal integrity and barrier function in dogs.

Animal experiment [2]:

Animal models£º

Dogs with chronic unilateral osteoarthritis of the stifle joint

Dosage form£º

10 days with a 30- to 60-day washout period

Application£º

Carprofen significantly suppressed PGE2 concentrations in blood at days 3 and 10. Carprofen significantly decreased gastric synthesis of PGE2 at day 3 but not day 10 of each treatment period. Carprofen decreased synovial fluid PGE2 concentrations in the affected and unaffected stifle joints at days 3 and 10.

Other notes£º

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

100mg

$55.00

€ 66.00

£¤550.00

£¤10,945.00

500mg

$220.00

€ 264.00

£¤2,200.00

£¤43,780.00

5g

$770.00

€ 924.00

£¤7,700.00

£¤153,230.00

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

273.71

Formula

C15H12CINO2

CAS Number

 53716-49-7

Purity

>98%

Solubility

11.05mg/mL in DMSO

Storage

at -20¡ãC

References Information

[1] Hicks M A, Hosgood G L, Morgan T W, et al. In vitro effect of carprofen and meloxicam on the conductance and permeability to mannitol and the histologic appearance of the gastric mucosa of dogs[J]. American journal of veterinary research, 2011, 72(4): 570-577.

[2] Sessions J K, Reynolds L R, Budsberg S C. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis[J]. American journal of veterinary research, 2005, 66(5): 812-817.

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